“Hold your anger like a baby” advises psychologist Wilbur Waskowicks. He has has just finished his first book, 'Anger Vanquished,' and hired exuberant temp Francesca to proofread. She has a thing for messy situations: she married her poetry professor Fernando who was fired as a result.
Francesca and Wilbur grow intimate, and when his book is published, abscond to Lake Tahoe for his book launching. Their affair is a brief dysfunctional glimpse of heaven that collides with reality when Wilbur gets the book’s dismal reviews. Two other couple’s stories intertwine: Joe, a meek screenwriter with three forceful ex-wives, four rambunctious kids assorted between them, and Stacey, a new girlfriend who might or might not be pregnant. And then there’s Angie and Angelo: a petite, foul-mouthed waitress aspiring to be a vet, insisting on couple’s therapy, and, a rough-hewn boxer who tends to put his foot in his mouth, and has finally gotten a shot at that title fight in Vegas -- but not without the juice.
On separate occasions Joe and Angelo each end up on the top of the “Asshole Avenger’s” hit list. Wilbur arranges a fight between them and in riotous mayhem the fight draws all our characters into a denouement of furiously funny proportions.