Stuart's (Michael J. Fox) older brother George (Jonathan Lipnicki) has a new friend and the lonely Stuart meets Margalo (Melanie Griffith), a tiny bird wounded by a falcon (James Woods). While Margalo's busted wing heals up the Littles' house, Stuart grows closer to her and falls in love, but his new pal is hiding a secret that involves the villainous falcon and jewelry theft. In order to save his friend and their friendship, Stuart must call upon the assistance of Snowbell (Nathan Lane).